About — Jong Seung Lee

Research experience

2021.3 – present

Postdoctoral Associate / Research Scientist

Massachusetts Institute of Technology Cambridge, MA, USA

2014.2 – 2021.2

Graduate Research Assistant

Stem Cell and Biomaterials Engineering Laboratory (PI: Seung-Woo Cho) Yonsei University, Seoul, Republic of Korea

Developing biomedical platform to manipulate stem cell and tissue engineeringIntra/extracellular electrical stimulation; photoactivated system; magnetic control
Organ-on-a-chip system developmentArtificial skin with neuronal interface; organoid culture system
Development of functionalized scaffolds for tissue regenerationNatural/synthetic polymer; hydrogel

2012.8 – 2013.7

Undergraduate Researcher

Nanobiotech Laboratory (PI: Prof. Hyung-il Jung) Yonsei University, Seoul, Republic of Korea

2025

1.Lim D, Park S, Lee JS, Gwon HJ, Nam Y, Choi S, Kim J, Kim Y, Park G, Pyun WY, Park HW, Cho SW, Ahn HS. Longitudinal transformation of mitochondrial metabolism during neurogenesis. PNAS 2025;122(47):e2517961122.
2.Jeon IY, Jeon YM, Choi JH, Lee S, Kim M, Kim JH, Lee JS, Hwang J, Jeong D, Carroll GA, Wentworth A, Yang K, Park S, Raskin KA, Jang WY, Traverso G, Lee JS. In situ printing of biodegradable implant for healing critical-sized bone defect. Device 2025;3:100873.
3.Kim J, Lee JS, Noh S, Seo E, Lee J, Kim T, Cho SW, Kim G, Kim SS, Park J. Cellular level cryo-neuromodulation using rapid and localized cooling device combined with microelectrode array. Biosensors and Bioelectronics 2025;277:117257.

2022

4.Lee JS*, Kim J*, Cui B, Kim SK, Cho SA, An S, Cho SW. Hybrid skin chips for toxicological evaluation of chemical drugs and cosmetic compounds. Lab on a Chip 2022;22:343-353.
5.Lee JS, Choi YS, Lee JS, Jeon EJ, An S, Lee MS, Yang HS, Cho SW. Mechanically-reinforced and highly adhesive decellularized tissue-derived hydrogel for efficient tissue repair. Chemical Engineering Journal 2022;427:130926.

2021

6.Kwon J*, Lee JS*, Lee J, Na J, Sung J, Lee HJ, Kwak H, Cheong E, Cho SW, Choi HJ. Vertical nanowire electrode array for enhanced neurogenesis of human neural stem cells via intracellular electrical stimulation. Nano Letters 2021;21:6343-6351.
7.Kim J, Lee KT, Lee JS, Shin J, Cui B, Yang K, Choi YS, Choi N, Lee SH, Lee JH, Bahn YS, Cho SW. Fungal brain infection modelled in a human-neurovascular-unit-on-a-chip with a functional blood-brain barrier. Nature Biomedical Engineering 2021;5:830-846.

2020

8.Choi S, Lee JS, Shin J, Lee MS, Kang D, Hwang NS, Lee H, Yang HS, Cho SW. Osteoconductive hybrid hyaluronic acid hydrogel patch for effective bone formation. Journal of Controlled Release 2020;327:571-583.
9.Baek J, Cho Y, Park H-J, Choi G, Lee JS, Lee M, Yu SJ, Cho SW, Lee E, Im SG. A surface-tailoring method for rapid non-thermosensitive cell sheet engineering via functional polymer coatings. Advanced Materials 2020;32(16):1907225.

2019

10.Jin Y, Lee J, Chung E, Yang K, Kim J, Kim JW, Lee JS, Cho AN, Oh T, Lee JH, Cho SW, Cheon J. Magnetic control of axon navigation in reprogrammed neurons. Nano Letters 2019;19(9):6517-6523.
11.Yang K, Lee JS, Han S, Jin Y, Cho AN, Chang GE, Cheong E, Yang JH, Chung S, Cho SW. Endothelial-neurosphere crosstalk in microwell arrays regulates self-renewal and differentiation of human neural stem cells. Journal of Industrial and Engineering Chemistry 2019;74:148-157.

2018

12.Ko E*, Lee JS*, Kim H, Yang SY, Yang D, Yang K, Lee J, Shin J, Yang HS, Ryu WH, Cho SW. Electrospun silk fibroin nanofibrous scaffolds with two-stage hydroxyapatite functionalization for enhancing the osteogenic differentiation of human adipose-derived mesenchymal stem cells. ACS Applied Materials & Interfaces 2018;10(9):7614-7625.

2017

13.Yang K, Yu SJ, Lee JS, Lee HR, Chang GE, Seo J, Lee T, Cheong E, Im SG, Cho SW. Electroconductive nanoscale topography for enhanced neuronal differentiation and electrophysiological maturation of human neural stem cells. Nanoscale 2017;9:18737-18752.
14.Lee JS, Jin Y, Park HJ, Yang K, Lee MS, Yang HS, Cho SW. In situ bone tissue engineering with an endogenous stem cell mobilizer and osteoinductive nanofibrous polymeric scaffold. Biotechnology Journal 2017;12(12):1700062.
15.Yang K, Oh JY, Lee JS, Jin Y, Chang GE, Chae SS, Cheong E, Baik HK, Cho SW. Photoactive poly(3-hexylthiophene) nanoweb for optoelectrical stimulation to enhance neurogenesis of human stem cells. Theranostics 2017;7(18):4591-4604.
16.Lee JS, Lee JS, Lee MS, An S, Yang K, Lee K, Yang HS, Lee H, Cho SW. Plant flavonoid-mediated multifunctional surface modification chemistry: catechin coating for enhanced osteogenesis of human stem cells. Chemistry of Materials 2017;29(10):4375–4384.
17.Kim J, Yang K, Lee JS, Hwang YH, Park HJ, Park KI, Lee DY, Cho SW. Enhanced self-renewal and accelerated differentiation of human fetal neural stem cells using graphene oxide nanoparticles. Macromolecular Bioscience 2017;17(8):1600540.

2016

18.Kim H, Yang K, Jeong W, Choi S, Lee JS, Cho AN, Chang G-E, Cheong E, Cho SW, Lim Y. Photoactivation of noncovalently assembled peptide ligands on carbon nanotubes enables the dynamic regulation of stem cell differentiation. ACS Applied Materials & Interfaces 2016;8(16):26470-26481.
19.Shin J, Cho JH, Jin Y, Yang K, Lee JS, Park HJ, Han HS, Lee J, Jeon H, Shin H, Cho SW. Mussel adhesion-inspired reverse transfection platform enhances osteogenic differentiation and bone formation of human adipose-derived stem cells. Small 2016;12(45):6266-6278.
20.Ko E, Alberti K, Lee JS, Yang K, Jin Y, Shin J, Yang HS, Xu Q, Cho SW. Nanostructured tendon-derived scaffolds for enhanced bone regeneration by human adipose-derived stem cells. ACS Applied Materials & Interfaces 2016;8(35):22819-22829.
21.Yang K, Lee J, Lee JS, Kim D, Chang G-E, Seo J, Cheong E, Lee T, Cho SW. Graphene oxide hierarchical patterns for the derivation of electrophysiologically functional neuron-like cells from human neural stem cells. ACS Applied Materials & Interfaces 2016;8(28):17763-17774.

2015

22.Yang K, Park E, Lee JS, Kim IS, Hong K, Park KI, Cho SW, Yang HS. Biodegradable nanotopography combined with neurotrophic signals enhances contact guidance and neuronal differentiation of human neural stem cells. Macromolecular Bioscience 2015;15(10):1348-1356.
23.Yang K, Park HJ, Han S, Lee J, Ko E, Kim J, Lee JS, Yu JH, Song KY, Cheong E, Cho SR, Chung S, Cho SW. Recapitulation of in vivo-like paracrine signals of human mesenchymal stem cells for functional neuronal differentiation of human neural stem cells in a 3D microfluidic system. Biomaterials 2015;63:177-188.

2014

24.Yang K, Jung H, Lee HR, Lee JS, Kim SR, Song KY, Cheong E, Bang J, Im SG, Cho SW. Multiscale, hierarchically patterned topography for directing human neural stem cells into functional neurons. ACS Nano 2014;8(8):7809-7822.